A Selective Estrogen Receptor Modulator, Clomid by design binds to the receptors thereby preventing estrogen from binding; in simplistic terms it takes estrogens place at this binding point and this can serve and bring about several benefits to the intended individual. While binding to the receptors Clomid also simultaneously increases the release of both Luteinizing and Follicle Stimulating Hormones (LH & FSH) by way of stimulation; as both LH and FSH are imperative to testosterone production, without testosterone declines, through this direct stimulation natural testosterone production is increased. For the performance enhancer this presents two distinct benefits, one for On-Cycle protection by the receptor binding and one for Post Cycle Therapy (PCT) in-terms of re-stimulating proper natural hormonal production. For the treatment of low testosterone we can also easily begin to see the purpose, as increased LH and FSH lend to the desired end.
For the anabolic androgenic steroid user there are three distinct benefits separated into two distinct categories; therapeutic testosterone replacement and performance enhancement. As we are aware many anabolic steroids convert into estrogen once present in the human body and never is this truer than with the advent and presence of exogenous testosterone. The cause of this estrogen conversion is largely brought on by what is commonly referred to as the aromatase process and it is this process that can lead to many of the most commonly known steroidal side-effects. Estrogen buildup is largely responsible for the brunt of anabolic steroid related side-effects and perhaps the most threatening for many is Gynecomastia or what is commonly known as Gyno or male breast enlargement. It is true, Clomid will do very little to reduce the total amount of estrogen in the body, in-fact it really wont do anything at all but it can prevent the existing estrogen from binding to the receptors of the pectoral region thereby preventing the onset of Gynecomastia. It is important to note, while this binding at the receptors can be very efficient it is limited in action; those who are extremely sensitive or who have a greater buildup of estrogen than Clomid can bind will find this SERM to be useless in-terms of side-effect prevention. For this individual only an active aromatase inhibitor will do; in the case of this individual we need a medication that not only inhibits estrogen from existing by conversion but one that actively reduces the total amount as well; this is where Arimidex and Letrozole really become invaluable.
Doses & Cycles:
As Clomid side-effects are very rare and extremely mild if they occur at all, Clomid can be used for far extended periods of time if necessary; one could safely and effectively supplement with Clomid the entire duration of a cycle to prevent Gynecomastia if proven necessary. While Nolvadex is far more common to meet this end a simply dosing of 25mg of Clomid every day can in many cases be sufficient to prevent certain aromatase related side-effects while on cycle. However, many in the performance enhancing world will find this to be lacking as their doses of anabolic steroids will necessarily be high and stronger aromatase inhibitors will be needed.
Without question it is during the PCT period most will find Clomid to be the most beneficial and without question the most common time period in-which this SERM will be used. The majority of performance enhancers will find a 4 week total PCT period to be very efficient with 3 weeks of the total period consisting of Clomid. For example, a solid PCT schedule might include a 10-12 day period of hCG use followed by 3 weeks of Clomid therapy. Generally, a dosing of 150mg every day for one week followed by 2 weeks at 100mg can be very effective but depending on the individual some will need more time and another week or two at 50-100mg per day should suffice in this instance.