Your shopping cart is empty!
Physiology of IGF-1
IGF-1, also called Somatomedin-C, is a growth peptide. Many tissues of our body can generate IGF-1, among which the main resource is liver. Under the control of Growth hormone, liver can synthetize and secrete IGF-1.
Growth hormone, GH, was secreted by anterior pituitary. The main functions are to control the growth of internal cells, skeleton and muscle, and to maintain organ function.
Secreted GH enters blood, and then is absorbed by liver. Finally, it transforms into different growth factors, among which the most important growth factor is IGF-1(Insuin -like growth factor). Almost all the functions of the growth hormone need the collaboration with IGF-1, including the promotion of bone growth, protein synthesis, muscle tissue generation, fats loss, cholesterol reduction, glucose and electrolyte regulation. Thus, someone called IGF-1 as a channel.
What is the difference of functional mechanism between IGF-1 and IGF-1 LR3 in the body of human beings?
As stated before, IGF-1 is a growth factor that is similar to insulin in structure. These hormones are produced when liver is stimulated by GH nerve, which is secreted by pituitary gland and sent by transmitter from hypothalamus.
While IGF-1 LR3(Insulin Growth Factor-1 Long Arginine 3), also known as IGF, belongs to proteins, which play a very important role in the growth and development of mammals. IGF-1 LR3 is also referred to as Long R3 IGF-1 and IGF-I-Arg-Arg3.
The reason that LR3 IGF-1 is more effective than conventional IGF-1 is that IGF-1 LR3 has a low binding protein binding rate compared with pure IGF, and these binding proteins usually inhibit the biological effects of IGF. Therefore, it has been proved that IGF-1 LR3 is more effective and functional than IGF.
IGF-1 LR3 analogues extended by IGF-1 are produced to increase the bioactivity of IGF pep tides.IGF-1 LR3 is also referred to as Long R3 IGF-1 and IGF-I-Arg-Arg3, which is a non-glycosylated polypeptide bonds of 9200 molecular weight and contains 83 amino acids. IGF-1 growth factor (GH; MIM139250) promotes a lot of growth. GF-1 LR3 is of long chain, similar to human GF - 1, specially designed and manufactured for mammalian cells to support mass production of drugs. Early studies have shown that growth hormone does not directly to get into the cartilage by stimulating sulphate but by the Serum factor, called sulphation factor, which is later called growth factor.
Together with the use of steroid, GF-1 will increase the stimulation intensity and physical properties of steroids, and the strength and endurance of users (the ability to increase satellite cells). The most effective form of GF - 1 is considered to be GF - 1 LR3. The structure has been chemically altered to avoid binding to proteins in humans and increasing the half-life period, which can last up to 20-30 hours in human body.
Correlation between IGF-1 LR3 and muscle growth
IGF-1 LR3 can help to increase the biological activity of IGF peptides, the most active of which is to improve the efficiency of amino acids, glucose utilization, and to promote protein synthesis but reduce its decomposition. In energy conversion, existing in adipose tissue, IGF-1 LR3 will promote fat to produce energy, but in muscle tissue, IGF-1LR3 can prevent insulin from transporting glucose in the cell membrane. It can also enhance the absorption of protein synthesis and amino acid. Therefore, insulin can get glucose into your cells, which will be transferred as fuel to burn fat.
IGF-1 LR3 creates new muscle cells by promoting nitrogen retention and protein synthesis, through the hyperplasia, the muscle could grow accompanied with the increasing of muscle cell and new muscle fiber. Thus, IGF-1 LR3 has a good effect on muscle cells and fiber. Compared with steroids, it makes muscle growth more effective. In short, IGF can not only alter genetic ability in muscle tissue and cell count, but increase and distinguish the number and type of cells present.
The half-life of IGF-1 LR3 and its effect on IGF-1
IGF-1 LR3 has a much longer half-life than other forms, nearly 20-30 hours. When IGF-1 LR3 is active, IGF-1 LR3 promotes stem cell growth and division in a variety of roles in muscle cells. IGF-1 LR3 enhances satellite cell viability, DNA and protein content, weight as well as cross-sectional area of muscle; IGF-1 LR3 is important in that it can significantly promote muscle growth. Combined with weight training and steroid, these effects are visibly improved.
Side effects of IGF-1
Athletes and bodybuilders often use these drugs to enhance muscle growth, strength and endurance, including HGH, IGF-1, STEROID, SARMS etc.
IGF can improve the anabolism capacity, many fitness sites and the study of peptides showed peptide hormone injection can affect the endocrine system and metabolism. It Can lower the blood glucose, but it will promote all tissue growth, thus enhancing tumor cell growth, in addition, the headache is the common side effect of injection.
The applications of IGF-1 on anti-aging
In recent years, IGF have been the focus of many researchers. They regard IGF as the most important “Youth-promotion factor”. So far, there is no material can be compared to IGF in slowing down the process of aging. Researchers find that appropriate concentration of IGF-1 can reduce all the symptoms of aging and make people live longer, healthier and more energetically, because IGF-1 can condense the muscle, reduce fat and help rebuild the muscle, bone and nerve.
There are many benefits of GIF-1, but unfortunately, after 30 years old, the secretion of GH significantly decreases. Influenced by the reduction of GH, the synthetic amount of IGF-1 is also reduced. The study found that after 21 years old to 31 years old, the GF secretion of body decreased by 14% every decade. So when in 30 years old, the secretion is half of the youth. When in 80 years old, the secretion is only 1/5 of youth.
According to the published report, the imbalance of IGF-1 in body will cause the following diseases, including prostate cancer, infertility, strain after trauma and the difficulties of the recovery after surgical trauma. Therefore, in terms of anti-aging, the elderly test the concentration of IGF-1 in blood have the following benefits:
1. assess the maintenance of bone density.
2. Asses the ability of preventing the neural decline. (ability to resist a slow response)
3. Assess the ability of physical decline and recovery after trauma or stress.
4. Assess the ability of against the loose muscle and maintaining muscle elasticity.
5. Assess the ability of keeping the skin color.
6. Asses the ability of reduce the chances of cardiovascular morbidity, (reduce the side effects of steroids).
All in all, IGF-1 have the following effects:
1. using fat as the main energy source to achieve cutting.
2. Contributing to rejuvenation.
3. Increasing the efficiency of nutrient transmission, such as protein synthesis
4. Increasing the capacity of repair and regeneration of nerve cell.
5. increasing the ability of cell fibrosis, so you have more powerful muscle.